Publicações

Principais Publicações do SIAT

  1. Gomes JDA, Kowalski TW, Fraga LR, Macedo GS, Sanseverino MTV, Schüler-Faccini L, Vianna FSL. The role of ESCO2, SALL4 and TBX5 genes in the susceptibility to thalidomide teratogenesis. Sci Rep. 2019 Aug 6;9(1):11413. (https://doi.org/10.1038/s41598-019-47739-8)

  2. Kowalski TW, Dupont ÁV, Rengel BD, Sgarioni E, Gomes JDA, Fraga LR, Schüler-Faccini L, Vianna FSL. Assembling systems biology, embryo development and teratogenesis: What do we know so far and where to go next? Reprod Toxicol. 2019 Sep;88:67-75. (https://doi.org/10.1016/j.reprotox.2019.07.015)

  3. Vianna P, Gomes JA, Boquett JA, Fraga LR, Schuch JB, Vianna FSL, Schüler-Faccini L. Zika Virus as a Possible Risk Factor for Autism Spectrum Disorder: Neuroimmunological Aspects. Neuroimmunomodulation. 2019. 26: 1-8. (https://doi.org/10.1159/000495660)

  4. Herber S, Silva AA, Sanseverino MTV, Friedrich L, Ranieri TMS, Favreto C, Fraga LR, Terra AP, Schwartz IVD, Schüler-Faccini L. Prevalence and causes of congenital microcephaly in the absence of a Zika virus outbreak in southern Brazil. J Pediatr (Rio J). 2019; 95:600-606. (https://doi.org/10.1016/j.jped.2018.05.013)

  5. Giugliani R, Bender F, Couto R, Bochernitsan A, Brusius-Facchin AC, Burin M, Amorim T, Acosta AX, Purificação A, Leistner-Segal S, Saraiva-Pereira ML, Jardim LB, Matte U, Riegel M, Cardoso-Dos-Santos AC, Rodrigues G, Oliveira MZ,Tagliani-Ribeiro A, Heck S, Dresch V, Schüler-Faccini L, Kubaski F. Population medical genetics: translating science to the community. Genet Mol Biol. 2019; 42(suppl):312-320. (https://doi.org/10.1590/1678-4685-GMB-2018-0096)

  6. Schüler-Faccini L, Sanseverino MTV, Abeche AM, Vianna FSL, Fraga LR, Rocha AG, Silva AA da, Souza PRA de, Hilgert AH, Barbosa CP, Kauppinem CG, Martins DF, Santos DS, Colpes GH, Ecco G, Silva HMFS da, Penteado LP, Santos T dos. From abortion-inducing medications to Zika Virus Syndrome: 27 years experience of the First Teratogen Information Service in Latin America. Genetics and Molecular Biology (online version). 2019, Apr. 11: S1415-475720190. (https://doi.org/10.1590/1678-4685-gmb-2018-0111)

  7. Gomes JA, Kowalski TW, Fraga, LR, Tovo-Rodrigues L, Sanseverino MTV, Schüler-Faccini L, Vianna FSL. Genetic susceptibility to thalidomide embryopathy in humans: Study of candidate development genes. Birth Defects Research. 2018. 110: 456-461. (https://doi.org/10.1002/bdr2.1163)

  8. Schüler-Faccini L. An anthropological view on the emerging threat of Zika virus. Lancet Infectious Diseases. 2018. v. online, p. 1. (https://doi.org/10.1016/S1473-3099(18)30135-X)

  9. Cardoso GC, Oliveira MZ de, Paixão-Côrtes VR, Castilla EE, Schüler-Faccini L. Clusters of genetic diseases in Brazil. Journal of Community Genetics. v. online, p. 1-8. (https://doi.org/10.1007/s12687-018-0369-1)

  10. Fortis MF, Fraga LR, Boquett JA, Kowalski TW, Dutra CG, Gonçalves RO, Vianna FSL, Schüler-Faccini L, Sanseverino MTV. Angiogenesis and oxidative stress-related gene variants in recurrent pregnancy loss. Reproduction Fertility and Development. 2018. 30: 498. (https://doi.org/10.1071/RD17117)

  11. Barbeito-Andrés J, Schüler-Faccini L, Garcez PP. Why is congenital Zika syndrome asymmetrically distributed among human populations? Plos Biology. 2018. 16: e2006592. (https://doi.org/10.1371/journal.pbio.2006592)

  12. Moorthie SB, Hannah D, Lawn MW, Morris J, Modell JK, Bittles B, Blencowe AH, Christianson H, Cousens A, Darlison S, Gibbons MW, Hamamy S, Khoshnood H, Howson B, Lawn CP, Mastroiacovo J, Modell P, Moorthie B, Morris S, Mossey JK, Neville PA, Petrou M, Povey S, Rankin J. et al. Estimating the birth prevalence and pregnancy outcomes of congenital malformations worldwide. Journal of Community Genetics. 2018, Sep 17. p. 1-10. (https://doi.org/10.1007/s12687-018-0384-2)

  13. Tovo-Rodrigues L, Schneider BC, Martins-Silva T, Del-Ponte B, Loret de Mola C, Schüler-Faccini L, Vianna FSL, Munhoz TN, Entiauspe L, Silveira MF, Santos IS, Matijasevich A, Barros AJD, Rohde L, Bertoldi AD. Is intrauterine exposure to acetaminophen associated with emotional and hyperactivity problems during childhood? Findings from the 2004 Pelotas birth cohort. BMC Psychiatry. 2018. 18: 368-378. (https://doi.org/10.1186/s12888-018-1942-1)

  14. Silva JH da, Terças ACP, Pinheiro LCB, França GVA de, Atanaka M, Schüler-Faccini L. Perfil das anomalias congênitas em nascidos vivos de Tangará da Serra, Mato Grosso, 2006-2016*. Epidemiologia e Serviços de Saúde. 2018. 27: e2018008. (https://doi.org/10.5123/s1679-49742018000300017)

  15. Schüler-Faccini L, Roehe P, Zimmer ER, Quincozes-Santos A, De Assis AM, Lima EOC, Guimarães JA, Victora C, Neto VM, Souza DO. ZIKA Virus and Neuroscience: the Need for a Translational Collaboration. Molecular Neurobiology. 2018.  (https://doi.org/10.1371/journal.pone.0169287)

  16. Mazzu-Nascimento T, Melo DG, Morbioli GG, Carrilho E, Vianna FSL, Silva AAD, Schüler-Faccini L. Teratogens: a public health issue – a Brazilian overview. Genet Mol Biol. 2017; 40:387-397. (https://doi.org/10.1590/1678-4685-GMB-2016-0179)

  17. Del Campo M, Feitosa IM, Ribeiro EM, Horovitz DD, Pessoa AL, França GV, García-Alix A, Doriqui MJ, Wanderley HY, Sanseverino MV, Neri JI, Pina-Neto JM, Santos ES, Verçosa I, Cernach MC, Medeiros PF, Kerbage SC, Silva AA, van der Linden V, Martelli CM, Cordeiro MT, Dhalia R, Vianna FSL, Victora CG, Cavalcanti DP, Schüler-Faccini L. Zika Embryopathy Task Force-Brazilian Society of Medical Genetics ZETF-SBGM. The phenotypic spectrum of congenital Zika syndrome. Am J Med Genet A. 2017 Apr;173(4):841-857. (https://doi.org/10.1002/ajmg.a.38170)

  18. Fortis MF, Fraga LR, Boquett JA, Kowalski TW, Dutra CG, Gonçalves RO, Vianna FSL, Schüler-Faccini L, Sanseverino MTV. Angiogenesis and oxidative stress-related gene variants in recurrent pregnancy loss. Reprod Fertil Dev. Aug 22, 2017. (https://doi.org/10.1071/RD17117)

  19. Kowalski TW, Fraga LR, Tovo-Rodrigues L, Sanseverino MT, Hutz MH, Schüler-Faccini L, Vianna FS. Angiogenesis-related genes and thalidomide teratogenesis in humans: an approach on genetic variation and review of past in vitro studies. Reprod Toxicol. pii: S0890-6238(17)30054-0, 2017. (https://doi.org/10.1016/j.reprotox.2017.01.012)

  20. Vianna FSL, Kowalski TW, Fraga LR, Sanseverino MT, Schüler-Faccini L. The impact of thalidomide use in birth defects in Brazil. Eur J Med Genet.;60(1):12-15. i: 2017 (https://doi.org/10.1016/j.ejmg.2016.09.015)

  21. França GV, Schüler-Faccini L, Oliveira WK, Henriques CM, Carmo EH, Pedi VD, Nunes ML, Castro MC, Serruya S, Silveira MF, Barros FC, Victora CG. Congenital Zika virus syndrome in Brazil: a case series of the first 1501 livebirths with complete investigation. ;388(10047):891-7. 2016 (https://doi.org/10.1016/S0140-6736(16)30902-3)

  22. Schüler-Faccini L, Sanseverino M, Vianna FSL, da Silva AA, Larrandaburu M, Marcolongo-Pereira C, Abeche AM. Zika virus: A new human teratogen? Implications for women of reproductive age. Clin Pharmacol Ther;100(1):28-30. 2016 (https://doi.org/10.1002/cpt.386)
  23. Feitosa IM, Schüler-Faccini L, Sanseverino MTV. Aspectos Importantes da Síndrome da Zika Congênita para o Pediatra e Neonatologista. Boletim Científico de Pediatria – Vol. 5, N° 3, 2016.

  24. Vianna FSL, Kowalski TW, Tovo-Rodrigues L, Tagliani-Ribeiro A, Godoy BA, Fraga LR, Sanseverino MTV, Hutz MH, Schüler-Faccini L. Genomic and in silico analyses of CRBN gene and thalidomide embryopathy in humans. Reprod Toxicol; 66:99-106. 2016 (https://doi.org/10.1016/j.reprotox.2016.10.003)

  25. Victora CG, Schüler-Faccini L, Matijasevich A, Ribeiro E, Pessoa A, Barros FC. Microcephaly in Brazil: how to interpret reported numbers? Lancet. 2016 13;387(10019):621-4. 2016 (https://doi.org/10.1016/S0140-6736(16)00273-7)

  26. Schüler-Faccini L, et al. Possible Association Between Zika Virus Infection and Microcephaly – Brazil, 2015. MMWR Morb Mortal Wkly Rep. 2016 Jan 29;65(3):59-62. 2016 (https://doi.org/10.15585/mmwr.mm6503e2)

  27. Bronberg R, Dipierri J, Alfaro E, Sanseverino MTV, Schüler-Faccini L. Primary prevention of neural tube defects in Brazil: insights into anencephaly. J Community Genet, 7: 97-105.

  28. Vianna FSL, De Oliveira MZ, Sanseverino MTV, Morelo EF, Neto DL, Lopez-Camelo J,  Schüler-Faccini L. Pharmacoepidemiology and Thalidomide Embryopathy Surveillance in Brazil. Reprod Toxicol 53: 63-67, 2015

  29. Kowalski TW, Sanseverino MTV, Schüler-Faccini L, Vianna FSL. Thalidomide Embryopathy: Follow-up of Cases Born between 1959 and 2010. Birth Defects Research. Clin and Molecular Teratology 103: 794-803, 2015.

  30. Larrandaburu M, Matte U, Noble A, Olivera Z, Sanseverino MTV, Nacul L, Schüler-Faccini L. Ethics, Genetics and Public Policies in Uruguay: Newborn and Infant Screening as a Paradigm. Journal of Community Genetics, 6:241-9, 2015.

  31. Fraga LR, Boquett JA, Dutra CG, Vianna FSL, Heck C, Goncalves RO, Paskulin DD, Costa OL, Ashton-Prolla P, Sanseverino MTV; Schüler-Faccini L. Interaction between TP63 and MDM2 genes and the risk of recurrent pregnancy loss. Eur J Obstet Gynecol Reprod Biol. 2014,182:7-10.

  32. Schüler-Faccini L, Castilla EE. From rumors to genetic isolates. Genetics and Molecular Biology 37:186-193, 2014 (https://doi.org/10.1590/S1415-47572014000200005)

  33. Fraga LR, Dutra CG, Boquett JA, Vianna FSL, Gonçalves RO, Paskulin DD, Costa OL, Ashton-Prolla P, Sanseverino MTV, Schüler-Faccini L. p53 signaling pathway polymorphisms associated to recurrent pregnancy loss. Mol Biol Rep.3:1871-7, 2014 (https://doi.org/10.1007/s11033-014-3036-6)

  34. Dutra CG, Fraga LR, Nácul AP, Passos EP, Gonçalves Ro, Nunes Ol, Godoy BA, Leistner-Segal S, Vianna, FSL, Schüler-Faccini, L, Sanseverino, MTV. Lack of association between thrombophilic gene variants and recurrent pregnancy loss. Human Fertility 17:99-105 2014.

  35. Silva AA, Ranieri TMS, Torres FD, Vianna FSL, Paniz GR, Schüler-Faccini L. Sanseverino MTV. Impact on Pregnancies in South Brazil from the Influenza A (H1N1) Pandemic: Cohort Study. 2014, PLoS ONE 9(2): e88624.

  36. Vianna FSL, Fraga LR, Tovo-Rodrigues L, Tagliani-Ribeiro A, Biondi F, Maximino CM, Sanseverino MTV, Hutz MH, Schüler-Faccini L. Polymorphisms in the endothelial nitric oxide synthase gene in thalidomide embryopathy. Nitric Oxide 35: 89-92, 2013. (https://doi.org/10.1016/j.niox.2013.09.002)

  37. Bronberg R, Schüler-Faccini L, Ramallo V, Alfaro E, Dipierri J. Spatial and temporal analysis of infant mortality from congenital malformations in Brazil (1996-2010). Journal of Community Genetics, 5: 269-282, 2013. (https://doi.org/10.1007/s12687-013-0170-0)

  38. Schüler-Faccini L, Sanseverino MTV, Rocha-Azevedo LM, Moorthie S, Alberg C, Chowdhury S, Sagoo G, Burton H, Nacul L. Health needs assessment for congenital anomalies in middle-income countries: Examining the case for neural tube defects in Brazil. J Comm Genet, 5:147-155, 2013

  39. Vianna FSL, Schüler-Faccini L, Leite JCL, De Sousa SHC, Da Costa LMM, Dias M, Morelo EF, Doriqui MJR, Maximino CM, Sanseverino MTV. Recognition of the phenotype of thalidomide embryopathy in countries endemic for leprosy. Clinical Dysmorphology, 22:59-63, 2013.

  40. Salazar-Granara A, Galvan M, Sanseverino MTV, Abeche AM, Schüler-Faccini L. First Inventory of Herbal Medicines Consumed by Brazilian Women During Pregnancy. Reproductive Toxicology 37: 79, 2013.

  41. Momino W, Félix TM, Abeche AM, Zandoná DI, Scheibler GG, Chambers C, Jones KL, Flores RZ and Schüler-Faccini L (2012) Maternal drinking behavior and Fetal Alcohol Spectrum disorders in adolescents with criminal behavior in southern Brazil. Genet Mol Biol 35:960–965

  42. Vianna FSL, Lopez-Camelo JS, Leite JCL, Sanseverino MTV, Dutra MG, Castilla EE, Schüler-Faccini L. Epidemiological Surveillance of Birth Defects Compatible with Thalidomide Embryopathy in Brazil. Plos One 6: e21735, 2011.

  43. Momino W, Sanseverino MTV, Schüler-Faccini L. Prenatal alcohol exposure as a risk factor for dysfunctional behaviors: the role of the pediatrician. J Pediatr (Rio J). 2008;84(4 Suppl): S76-79.

  44. Minussi L, Mohrdieck R, Bercini M,Ranieri T, Sanseverino MTV, Momino W, Callegari-Jacques SM, Schüler-Faccini L (2008) Prospective Evaluation of Women Vaccinated Against Rubella in Southern Brazil. Reprod Toxicol 25:120-3

  45. Pizzol TSD ,Schüler-Faccini L, Mengue SS, Fischer MI. Dipyrone Use During Pregnancy and Adverse Perinatal Outcomes. Archives of Gynecology and Obstetrics 278: 06, 2008.

  46. Schüler-Faccini L, Soares RC, Luna EM, Sousa AC, Maximino C, Waldmann C, Schwartz IVD, Castilla EE. New cases of Thalidomide Embriopathy in Brazil. Birth Defects Research. Clinical and Molecular Teratology 8: 114300662, 2007.

  47. Garbis H, Elefant E, Citrin OD, Mastroiacovo P, Schaefer C, Vial T, Clementi M, Valti E, Mcelhatton P, Smorlesi C, Rodriguez EP, Gnansia ER, Merlob P, Pexieder T, Peiker G, Schüler-Faccini L, Ritvanen A, Nolf MM. Pregnancy Outcome After Exposure to Ranitidine and other H2-blockersA Collaborative Study of the European Network of Teratology Information Services. Reproductive Toxicology 19: 453-458, 2005.

  48. Garcias GDL and Schüler-Faccini L (2004) The beliefs of mothers in southern Brazil regarding risk-factors associated with congenital abnormalities. Genet Mol Biol 27:147–153.

  49. Momino W, Minussi L, Woffchuck D, Palmero EI,  Sanseverino MTV, Guimarães, Schüler-Faccini L (2003) Reproductive Risk Factors Related to Socioeconomic Status in Pregnant Women in Southern Brazil. Comm Genet 6: 77-83

  50. Moretti M, Caprara D, Coutinho C, Baroz B, Berkovitch M, Addis A, Jovanovski E, Schüler-Faccini L, Koren G (2003) Fetal Safety of Loratadine Use in the First Trimester of Pregnancy: A Multicenter Study. J Allerg Clin Immunol 111: 479-83

  51. Lima Garcias G, Schüler-Faccini L. Community Diagnosis of Maternal Exposure to Risk Factors for Congenital Defects. Community Genetics 6(2): 96-103, 2003.

  52. Oliveira LM, Stein N, Sanseverino MTV, Vargas VMF, Fachel JMG, Schüler-Faccini L. (2002) Reproductive Outcomes in an Area Adjacent to a Petrochemical Plant in Southern Brazil. Revista de Saúde Pública/Journal of Public Health 36: 81-7

  53. Peres RM, Segal J, Carvalho CA, Moser C, Sanseverino MTV, Schüler-Faccini L. Fetal Hazards Associated with the Use of Benzodiazepines During Pregnancy: A Review. Jornal Brasileiro de Psiquiatria 51(3): 145-151, 2002.

  54. Schüler-Faccini L, Leite JCL, Sanseverino MTV, Peres RM (2002) Avaliação de Teratógenos Potenciais na População Brasileira. Ciência & Saúde Coletiva 7: 65-71

  55. Berkovitch M, Mazzota P, Greenberg R, Elbir D, Addis A, Schüler-Faccini L, Merlob P, Arnon J, Stahl B, Magee L, Moretti M, Ornoy A. Metoclopramide for Nausea and Vomiting of Pregnancy: a Prospective Multicenter International Study. American Journal of Perinatology 19:311-316, 2002.

  56. Leite JCL, Schüler-Faccini L. (2001) Defeitos Congênitos em uma Região de Mineração de Carvão. Revista de Saúde Pública/Journal of Public Health, Brasil 35(2): 136-41

  57. Koren G, Schüler-Faccini L. Taking Drugs During Pregnancy. Canadian Family Physician 47: 951-953, 2001.

  58. Einarson A, Fatoye B, Sarkar M, Lavigne SV, Borchu J, Chambers CD, Mastroiacovo P, Addis A, Matsui D, Schüler-Faccini L,  et al. (2001) Pregnancy Outcome Following Gestational Exposure to Venlafaxine: A Multicentre Prospective Controlled Study. Am J of Psych 158: 1728-30

  59. Sanseverino MTV, Spritzer DT, Schuler-Faccini L (Orgs.) (2001) Manual de Teratogênese. 1. ed. Porto Alegre: Editora da UFRGS, 556p

  60. Peres RM, Sanseverino MTV, Guimarães JLM, Coser V, Giuliani L, Moreira RK, Ornsten T, Schüler-Faccini L. Assessment of Fetal Risk Associated with Exposure to Cancer Chemotherapy During Pregnancy: A multicenter Study. Brazilian Journal of Medical and Biological Research 34: 1551-1559, 2001.

  61. Peres RM, Sanseverino MTV, Schüler-Faccini L. (2001) Exposição a Agentes Ambientais durante a Gestação e seus Efeitos sobre a Saúde Fetal: Uma revisão da literatura. Revista HCPA 3: 368-378.

  62. Vargas FR, Schüler-Faccini L, Brunoni D, Kim C, Meloni VFA, Sugayama SMM, Albano L, Llerena JC, Almeida JCC, Duarte A, Cavalcanti DP, Goloni-Bertollo E, Conte A, Koren G, Addis A. Prenatal Exposure to Misoprostol and Vascular Disruption Defects: A Case-Control Study. American Journal of Medical Genetics  95(4): 302-306, 2000.

  63. Berkovitch M, Schüler-Faccini L, Elbirt D, Addis A, Ornoy A. Fetal Effects of Metoclopramide Therapy for Nausea and Vomiting of Pregnancy. New England Journal of Medicine 343:445-46, 2000.

  64. Schüler-Faccini L, Pastuszak A, Sanseverino MTV, Orioli IM, Brunoni D, Ashton-Prolla P, Silva da Costa F, Giugliani R, Couto AM, Brandao SB and Koren G. (1999) Pregnancy outcome after exposure to misoprostol in Brazil: A prospective, controlled study. Reprod Toxicol 13:147–151.

  65. Pastuszak LA, Schüler-Faccini L, Speck-Martins CE, Coelho S, Cordello D, Schwartz IVD, Larrandaburu M. Use of Misoprostol During Pregnancy and Möbius’ Syndrome in Infants. New England Journal of Medicine 338(26): 1881-1885, 1998.

  66. Schüler-Faccini L, Pastuszak LA, Koren G. (1997) Misoprostol – A New Human Teratogen. The Motherisk Letter 1: 1-2.

  67. Castilla EE, Ashton-Prolla P, Barreda-Mejia, Brunoni D, Cavalcanti DP, Correa-Neto J, Delgadillo JL, Dutra MG, Félix TM, Giraldo A, Juarez N, Lopez-Camelo J, Nazer J, Orioli IM, Paz JE, Pessoto MA, Pina-Neto J, Quadrelli R, Schüler-Faccini L. Thalidomide, a Current Teratogen in South America. Teratology 54(6): 273-277, 1996.

  68. Brandão SB, Sanseverino MTV, Leite JCL, Souza CFM, Bremm M, Couto AM, Schüler-Faccini L. Riscos e Benefícios do Uso de Anticonvulsivantes na Gestação. Revista do HCPA 16(3): 289-294, 1996.

  69. Schüler-Faccini L, Ashton PW, Sanseverino MTV. (1992) Teratogenicity of Misoprostol. Lancet 339: 437

  70. Schüler-Faccini L, Sanseverino MTV, Clavijo HA, Ashton-Prolla PA, Boianowsky K, Pecis F, Costa FS, Tatto E, Wong V, Santos CV, Giugliani R. (1993) Preliminary Report on the First Brazilian Teratogen Information Service (SIAT). Brasil. Genet. 16: 1085-1095
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